Protein Flexibility from the Dynamical Transition:A Force Constant Analysis
نویسندگان
چکیده
منابع مشابه
Noninvasive protein structural flexibility mapping by bimodal dynamic force microscopy.
Mapping of the protein structural flexibility with sub-2-nm spatial resolution in liquid is achieved by combining bimodal excitation and frequency modulation force microscopy. The excitation of two cantilever eigenmodes in dynamic force microscopy enables the separation between topography and flexibility mapping. We have measured variations of the elastic modulus in a single antibody pentamer f...
متن کاملDetermination of protein structural flexibility by microsecond force spectroscopy.
Proteins are dynamic molecular machines having structural flexibility that allows conformational changes. Current methods for the determination of protein flexibility rely mainly on the measurement of thermal fluctuations and disorder in protein conformations and tend to be experimentally challenging. Moreover, they reflect atomic fluctuations on picosecond timescales, whereas the large conform...
متن کاملAnalysis of RNA flexibility by scanning force spectroscopy.
Scanning force spectroscopy was used to measure the mechanical properties of double stranded RNA molecules in comparison with DNA. We find that, similar to the B-S transition in DNA, RNA molecules are stretched from the assumed A' conformation to a stretched conformation by applying a defined force (plateau force). The force depends on the G + C content of the RNA and is distinct from that requ...
متن کاملReachability Analysis of Dynamical Systems Having Piecewise-Constant Derivatives
In this paper we consider a class of hybrid systems namely dy namical systems with piecewise constant derivatives PCD systems Such systems consist of a partition of the Euclidean space into a nite set of polyhedral sets regions Within each region the dynamics is de ned by a constant vector eld hence discrete transitions occur only on the boundaries between regions where the trajectories change ...
متن کاملForce Flexibility Modelling in BactoWars
Force flexibility is often referred to when considering the effectiveness of a force. Flexibility is all too often loosely defined and illcommunicated due to the number of factors involved and the nature of the English language. During the Army Experimental Framework Experiment Headline 2006 a key variable in determining a forces ability to continue its mission was the flexibility of the force ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2001
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(01)76089-4